Vitamin D: Production, Metabolism and Mechanisms of Action
Dec 31, 2021 · The potential role for vitamin D and its active metabolite 1,25(OH) 2 D 3 in modulating the immune response has long been recognized since the discovery of vitamin D receptors (VDR) in macrophages, dendritic cells (DC), and activated T and B lymphocytes, the ability of macrophages and DC as well as activated T and B cells to express CYP27B1 ...
Vitamin D - Wikipedia
Vitamin D has a significant role in calcium homeostasis and metabolism. [1] Its discovery was due to effort to identify the dietary deficiency in children with rickets, the childhood form of osteomalacia. [11] Vitamin D supplements are commonly used to treat or …
Vitamin D - Health Professional Fact Sheet
An FNB committee established RDAs for vitamin D to indicate daily intakes sufficient to maintain bone health and normal calcium metabolism in healthy people. RDAs for vitamin D are listed in both micrograms (mcg) and International Units (IU); 1 mcg vitamin D is equal to 40 IU (Table 2).
Overview of vitamin D - UpToDate
Sep 8, 2023 · Vitamin D is converted enzymatically in the liver to 25-hydroxyvitamin D (25[OH]D), the major circulating form of vitamin D, and then in the kidney to 1,25-dihydroxyvitamin D, the active form of vitamin D. Vitamin D and its metabolites have a significant clinical role because of their interrelationship with calcium homeostasis and bone ...
Vitamin D: Newer Concepts of Its Metabolism and Function at ...
Feb 1, 2020 · In this mini review I have focused primarily on recent studies that provide new insights into vitamin D metabolism, mechanisms of action, and clinical applications.
New aspects of vitamin D metabolism and action — addressing ...
Feb 6, 2020 · Vitamin D binding protein is the major transport protein for vitamin D metabolites, but with the exception of a few tissues such as the kidney, it is the free forms of these metabolites that...
Vitamin D: Metabolism, Molecular Mechanism of Action, and ...
Dec 17, 2015 · Vitamin D is transported in the blood by vitamin D binding protein (DBP; which binds vitamin D and its metabolites in serum) to the liver. In the liver, vitamin D is hydroxylated at C-25 to produce 25-hydroxyvitamin D 3 [25 (OH)D 3]. 25 (OH)D 3 …