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  1. Studies of Sprouty Erk
    PubMed
    The developing story of Sprouty and cancer
    Sprouty proteins are evolutionarily conserved modulators of MAPK/ERK pathway. Through interacting with an increasing number of effectors, mediators, and regulators with ultimate influence on multiple targets within or beyond ERK, Sprouty orchestrates a complex, multilayered regulatory system and med...
    Author: Samar Masou…
    Published: 2014/9
    Keywords: National In…
    National Center for Biotechnology Information
    Sprouty 1 predicts prognosis in human epithelial ovarian cancer
    Sprouty proteins are evolutionary-conserved modulators of receptor tyrosine kinase (RTK) signaling. We have previously reported inverse correlation of the Sprouty 1 (Spry1) protein expression with ovarian cancer cell proliferation, migration, invasion and survival. In the present study, the expressi...
    Author: Samar Masou…
    Published: 2015
    Publication: Am J Can…
    PubMed
    ERK pathway positively regulates the expression of Sprouty genes
    Sprouty was originally identified as an inhibitor of Drosophila development-associated receptor tyrosine kinase (RTK) signaling. Although RTK signaling has been shown to induce Sprouty gene expression, the precise induction pathway downstream of RTK remains unclear. As RTK signaling pathway includes...
    Author: K Ozaki
    Published: 2001/08/03
    Keywords: National In…
    National Center for Biotechnology Information
    The Sprouty/Spred family as tumor suppressors: Coming of age
    The Sprouty/Spred family functions as crucial negative regulators of Ras/Raf/ERK signaling and is evolutionarily conserved from Drosophila to mammals.1, 2, 3, 4 Drosophila sprouty was discovered as an antagonist of FGF signaling in 1998.1, 2 In mammals, there are four Sprouty homologs (Sprouty1‐4). ...
    Author: Tetsuro Kawaz…
    Published: 2019/05
    Publication: Cancer S…
    National Center for Biotechnology Information
    Sprouty2 and Spred1-2 Proteins Inhibit the Activation of the ERK Pathway Elicited by Cyclopentenone Prostanoids
    Sprouty and Spred proteins have been widely implicated in the negative regulation of the fibroblast growth factor receptor-extracellular regulated kinase (ERK) pathway. In considering the functional role of these proteins, we explored their effects on ERK activation induced by cyclopentenone prostan...
    Author: Carlota A. Gar…
    Published: 2011
    Publication: PLoS On…
    National Center for Biotechnology Information
    Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL
    SPRY2 is downregulated in CLL cells from patients with poor prognosis. SPRY2 is negative regulator of Syk-mediated BCR and MAPK-Erk signaling in CLL.
    Author: Ashima Shukla…
    Published: 2016/05/05
    Publication: Blood. 20…
  2. PubMed
    https://pubmed.ncbi.nlm.nih.gov/34048471

    Sprouty4 negatively regulates ERK/MAPK signaling and the

  3. PubMed
    https://pubmed.ncbi.nlm.nih.gov/24744103

    The developing story of Sprouty and cancer - PubMed

  4. Nature
    https://www.nature.com/articles/nrm1400

    Modulation of signalling by Sprouty: a developing story

    Jun 1, 2004 · SPRY exerts its inhibitory effect on RTK signalling by intercepting essential elements of the RAS–ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein kinase) cascade...

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    Hong Joo Kim, Dafna Bar-Sagi
    Publish Year:2004
    Hedgehog signaling pathway
  5. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/full/10.11…

    The Sprouty/Spred family as tumor suppressors: …

    24 rows · Mar 15, 2019 · The Sprouty/Spred family is broadly recognized as important negative regulators of the Ras/Raf/ERK pathway, and its expression is downregulated in many malignancies, leading to hyperactivation of the …

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    Publish Year:2019
    House of Sułkowski
  6. Nature
    https://www.nature.com/articles/ncb867

    Sprouty1 and Sprouty2 provide a control mechanism …

    Oct 28, 2002 · A tyrosine-phosphorylated octapeptide derived from mouse Spry2 inhibits Grb2 from binding FRS2, Shp2 or mouse Spry2 in vitro and blocks activation of the extracellular-signal-regulated kinase...

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    Publish Year:2002
    Nature Cell Biology
    MAPK/ERK pathway
  7. Springer
    https://link.springer.com/article/10.1007/…

    The developing story of Sprouty and cancer | Cancer …

    Apr 18, 2014 · At cellular level, Sprouty modulates key processes including proliferation, differentiation, motility, and survival through regulation of ERK and parallel pathways, as well as interaction with a number of effectors and …

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    Publish Year:2014
    Cancer
  8. People also ask
    How does Sprouty interact with ERK?
    Through interacting with an increasing number of effectors, mediators, and regulators with ultimate influence on multiple targets within or beyond ERK, Sprouty orchestrates a complex, multilayered regulatory system and mediates a crosstalk among different signaling pathways for a coordinated cellular response.

    The developing story of Sprouty and cancer - PubMed

    pubmed.ncbi.nlm.nih.gov
    How does Sprouty regulate ERK signaling?
    Sprouty is now recognized as a crucial regulator of ERK signaling that acts on different levels of the pathway. Furthermore, they are part of a tightly orchestrated regulatory mechanism where interactions with other regulators and effector molecules lay the basis for a crosstalk between ERK and partner pathways.

    Sprouty | SpringerLink

    link.springer.com
    Does Sprouty repress ERK?
    Sprouty is an interacting partner of the Gα o /GRIN pathway. GRIN modulates Sprouty repression of ERK by binding and sequestering Sprouty. Activated Gα o, on the other hand, promotes inhibition of ERK via interacting with GRIN and releasing Sprouty.

    The developing story of Sprouty and cancer - Springer

    link.springer.com
    Does Sprouty inhibit ERK activation?
    Yusoff, P. et al. Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf. J. Biol. Chem.277, 3195–3201 (2002). Sasaki, A. et al. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nature Cell Biol.5, 427–432 (2003).

    Modulation of signalling by Sprouty: a developing story

    nature.com
    Is Sprouty a negative regulator of the Ras/Raf/ERK pathway?
    The Sprouty/Spred family is broadly recognized as important negative regulators of the Ras/Raf/ERK pathway, and its expression is downregulated in many malignancies, leading to hyperactivation of the Ras/Raf/ERK pathway.

    The Sprouty/Spred family as tumor suppressors: Coming of age

    onlinelibrary.wiley.com
    Does Sprouty play a role in cancer?
    As a developing story, however, role of Sprouty in cancer remains to be further elucidated. Mitogen-activated protein kinase (MAPK) signaling pathways are among the most widespread regulatory mechanisms of the eukaryotic cell biology.

    The developing story of Sprouty and cancer - Springer

    link.springer.com
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  9. Nature
    https://www.nature.com/articles/s41419-024-06689-4

    Sprouty1 is a broad mediator of cellular senescence

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    Disease
    Death
  10. plos.org
    https://journals.plos.org/plosbiology/articl…

    Sprouty2 positively regulates T cell function and airway …

    Mar 8, 2021 · The ubiquitously expressed protein Sprouty2 (Spry2) is a known regulator of Ras/ERK signaling pathway. This study uses in vitro and in vivo models, as well as human specimens, to reveal a mechanism for Spry2 in …

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    Publish Year:2021
    Csk Asthma
    PLOS Biology
    T cell
  11. Springer
    https://link.springer.com/referenceworkentry/10...

    Sprouty - SpringerLink

  12. Springer
    https://link.springer.com/referenceworkentry/10...

    Sprouty - SpringerLink