Safflower has demonstrated antioxidant and anti-inflammatory activities and has been investigated for use (though often as a control or comparator agent) in cardiovascular conditions, diabetes, obesity, and pruritus. Animal studies also suggest reproductive, hair growth–promoting, and lung and tendon injury–attenuating effects.

Its seed oil is a rich source of the essential fatty acid, linoleic acid. The linoleic acid in safflower oil might help reduce the risk of heart disease. Safflower also contains chemicals that might help prevent blood clots, widen blood vessels, lower blood pressure, and stimulate the heart.

Safflower is a plant. The flower and oil from the seeds are used as medicine. Safflower seed oil is used for preventing heart disease, including “hardening of the arteries” (atherosclerosis) and stroke. It is also used to treat fever, tumors, coughs, breathing problems, clotting conditions, pain, heart disease, chest pain, and traumatic injuries.