Christian McCaffrey has missed all of their games because of his Achilles tendinitis. Brandon Aiyuk and Javon Hargrave will ...

The San Francisco 49ers face tough times with key players like Deebo Samuel, George Kittle, and Christian McCaffrey injured.

The San Francisco 49ers appear to be inching closer toward a return for star running back Christian McCaffrey. Head coach ...

San Francisco 49ers head coach Kyle Shanahan provided a brief update on running back Christian McCaffrey ahead of Wednesday's ...

Injuries have plagued the San Francisco 49ers this season, and now another one looms. Brock Purdy and company could lose yet ...

As expected, 49ers running back Christian McCaffrey won't return to practice this week. Head coach Kyle Shanahan confirmed that during his Wednesday news conference after noting on Monday that ...

Brandon Aiyuk has been placed on injured reserve, dealing a major blow to the 49ers as they navigate key injuries.

San Francisco 49ers head coach Kyle Shanahan provided a brief update on running back Christian McCaffrey ahead of Wednesday's ...

Every fan of the San Francisco 49ers is awaiting for Christian McCaffrey, and now HC Kyle Shanahan has provided a potential ...

It isn’t news that running back and reigning Offensive Player of the Year Christian McCaffrey is a key cog in the 49ers’ ...

Already missing star running back Christian McCaffrey to Achilles tendinitis in both his calves, the team also lost star wideouts Deebo Samuel and Brandon Aiyuk during Sunday's 28-18 loss to the ...

San Francisco 49ers head coach Kyle Shanahan told reporters that he would be surprised if star running back Christian ...