Here are five storylines to watch for during the lead-up to Bills vs. Colts: The Bills are favored over the Colts by 4.5 points to open the week. The home team typically receives a field-goal bump and that’s Indianapolis. But that’s for good reason this week.

Here's how the NFL experts around the league are viewing the Week 10 matchup between the Indianapolis Colts and Buffalo bills.

The Buffalo Bills (6-2) beat the Seattle Seahawks on Sunday, increasing their chances of making the playoffs slightly to 98 percent. The table below represents the Bills’ remaining games. Pick a winner and see what happens to the Bills’ playoff chances:

A spate of wrist injuries has hampered the Buffalo Bills. Rookie wide receiver Keon Coleman and defensive end Dawuane Smoot suffered wrist injuries in the second half of Buffalo's riveting 30-27 win over the Miami Dolphins.

The Kansas City Chiefs defensive tackle came to the defense of the city's culinary specialty and gave a shoutout to Bar-Bill Tavern. Smith, in his first year with the Dolphins, took several shots about the city of Buffalo, Bills Mafia and chicken wings as a guest on The Dive Bar podcast in July. He called Buffalo "the worst place you could be."

Keon Coleman could miss time with a wrist injury, while the Bills will be without Dawuane Smoot who will undergo surgery for a wrist injury.

The Buffalo Bills are defying preseason projections in suggesting they might struggle this year following an offseason roster overhaul.