The itching, redness and swelling of an allergic reaction are caused by mast cells—the vigilant first responders of the ...

New understanding of a receptor key to allergic responses and anaphylaxis in conditions like asthma could offer a new ...

Scratching an itchy rash really does make it worse, according to new research. But it can also provide defence against bacterial skin infections, say American scientists. New research, published in ...

To target CAR-T cells to CD22+ malignancies, the MAb m971 was used, which binds domains 5-7 of CD22 more proximal to the cell membrane than would Moxe. 5, 16 The CAR construct incorporates ...

Biological drugs have improved the lives of many people with severe asthma. However, a new study from Karolinska Institutet in Sweden shows that some immune cells with high inflammatory potential ...

BYL719 inhibits the migration, proliferation, and expression of pro-inflammatory cytokines in monocytes and mast cells, suggesting that BYL719 hampers the hyper-inflammatory status of HO lesions.

Mast cells are packed with substances which they release upon coming into contact with allergens. Blocking the responsible receptor prevents release, thus hindering a strong inflammatory reaction ...

In recent years, an increasing number of studies have shown that the inflammatory response plays a crucial role in the formation and development of pathological scars. Inflammation is a defensive ...

Novel mechanism of action (MOA) inhibits MRGPRX2 on both mast cells and peripheral sensory neurons - a key differentiator to other therapeutic options Potential first- and best-in-class safety and ...

Blueprint Medicines Corporation focuses on Ayvakit, BLU-808, and Elenestinib with strong potential in mast cell disorders. Read why BPMC stock is a strong buy.