A new study from the Kowalinski group at EMBL Grenoble characterized the structure of an important trypanosomal protein ...

Discover the potential of macrocycles in drug discovery: flexible, cell-permeable molecules targeting undruggable proteins.

Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical ...

Weill Cornell Medicine investigators have identified in a preclinical model a specific brain circuit whose inhibition appears ...

Therefore, there is the prospect of developing structure-based knowledge of ... where toxicity concerns could mean that a drug should only target one of a group of closely related proteins ...

But not all target proteins were receptive to this method, called structure-based drug design. The 3-D structure of many proteins remained unavailable, and many important proteins could not be ...

Bacterial cells differ fundamentally in their structure from animal ... molecules so special is that they target IspD, a protein that is not addressed by any drug currently on the market.

ACCG-2671 demonstrates potent target engagement and robust weight ... a robust pipeline and is leveraging its advanced structure-based drug discovery platform, underscoring its commitment to ...

"Since trypanosomes carry a special RNA cap structure, we were also interested ... lab who contributed to the publication. A potential drug target and future studies Because it is essential ...