The tissue adjacent to a tumor behaves differently than areas farther away. The tumor's cancerous cells influence their ...

Discover the potential of macrocycles in drug discovery: flexible, cell-permeable molecules targeting undruggable proteins.

Preclinical research findings from the University of North Carolina Lineberger Comprehensive Cancer Center have identified a ...

Antibiotics are a double-edged sword—they should be as toxic as possible to pathogenic bacteria while being harmless to the ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

While challenges remain, AI is accelerating the process by enabling researchers to identify and design new drug candidates ...

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the nomination of ISM1745, a potentially best-in ...

Glaucoma, the leading cause of blindness, is often marked by loss of retinal ganglion cells (RGCs). Necroptosis, a form of ...

Substance use before age 15 fundamentally changes brain structure, with research on 9,804 children showing specific patterns of damage. Early users display larger overall brain volume but dangerously ...

The starting point for all structure-based design work, whether ligand or protein based, is the choice of a suitable target. Antimicrobial-drug targets should be essential, have a unique function ...

The U.S. Food and Drug Administration (FDA) has proposed a new rule to require standardized testing of talc-containing cosmetics for asbestos, a known carcinogen linked to serious illnesses such ...