Scientists develop DNA nanorobots capable of modifying artificial cells. Scientists at the University of Stuttgart have ...

Discover the potential of macrocycles in drug discovery: flexible, cell-permeable molecules targeting undruggable proteins.

Proteins are the foundation of all life we currently know. With their virtually limitless diversity, they can perform a broad ...

Preclinical research findings from the University of North Carolina Lineberger Comprehensive Cancer Center have identified a ...

Antibiotics are a double-edged sword—they should be as toxic as possible to pathogenic bacteria while being harmless to the ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

Glaucoma, the leading cause of blindness, is often marked by loss of retinal ganglion cells (RGCs). Necroptosis, a form of ...

Target validation can include: determining the structure-activity-relationship of analogs of the small molecule; generating a drug-resistant mutant of the presumed target; knockdown or ...

Substance use before age 15 fundamentally changes brain structure, with research on 9,804 children showing specific patterns of damage. Early users display larger overall brain volume but dangerously ...

Individuals with SUD experience changes to the brain’s structure and function that cause cravings, personality and behavioral changes, and more. When drugs are introduced, the neurons sending and ...

The starting point for all structure-based design work, whether ligand or protein based, is the choice of a suitable target. Antimicrobial-drug targets should be essential, have a unique function ...