The discovery and development of GLP-1 receptor agonists for type 2 diabetes and obesity is a bench-to-bedside success story.1 Multiple GLP-1 receptor agonists are now in clinical use, such as ...

Certain nausea medicines, such as pyridoxine (vitamin B6) and Unisom (doxylamine), are safe to take during pregnancy to help ...

Serotonin is primarily synthesized by neurons in the dorsal Raphe nucleus (DRN) in the midbrain. Serotonin neurons in the DRN project to numerous brain regions, including the arcuate of the ...

As per the Brain and Behavior Research Foundation, it combines two compounds called xanomeline and trospium chloride. This is ...

C&EN’s tabulation follows approvals from the FDA’s Center for Drug Evaluation and Research; therefore, it does not include blood products, gene therapies, vaccines, and other therapies that ...

In October 2024, Bright Minds Biosciences Inc. a pioneering company focused on developing highly selective 5-HT2 agonists for the treatment of drug-resistant epilepsy, depression, and other CNS ...

The centre piece of this deal is lumateperone (Caplyta), an atypical antipsychotic with high affinity for serotonin 5-HT 2A receptors and moderate affinity for dopamine D 2 receptors. The FDA ...

The study, recently published in Cell Reports, explores how changes in dopamine (DA ... the problem to reduced activation of nicotinic receptors by acetylcholine, another neurotransmitter ...

US researchers analysed the use of GLP-1 receptor agonist drugs in health records from 2.4 million people with diabetes and also found a reduced risk of several substance use disorders; clotting ...

2012;46(5):710-717. There are several limitations to the available data. First, single-dose drug interaction studies do not permit examination of the effects of repeat dosing on the potential for ...

Weight-loss drugs like Ozempic may decrease your risk of developing 42 health conditions, but increase your chance of experiencing 19 others, according to one of the most comprehensive studies-of ...