A team of international researchers led by Karolinska Institutet has revealed in unprecedented detail how tetracycline ...

In a new study published in Science Bulletin, researchers from West China Hospital of Sichuan University present the largest ...

Activated T cells undergo metabolic reprogramming to optimize effector functions, but the underlying mechanisms remain elusive. Here the authors show, using knockout and tumor mouse models ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T ...

This Research Topic is the second volume of the “Immune Responses Against Tumors - From the Bench to the Bedside” Community Series. Please see Volume I ...

New research disentangles the risks for acute kidney injury related to CAR T-cell treatment in non-Hodgkin lymphoma, ...

Discovery of innate immune receptor "brake" Siglec-E offers a novel therapeutic target to prevent organ transplant rejection ...

Despite the massive successes of immunotherapy, which utilizes the body's immune system as a tool to fight cancer, therapy resistance is still a common treatment obstacle for many patients with solid ...

The study, published in Nature Cell Biology, highlights how the metabolic environment of tumors influences the function of T cells, which are critical immune cells responsible for eliminating cancer.

A team of international researchers led by Karolinska Institutet has revealed in unprecedented detail how tetracycline antibiotics impair T cell function by binding mitochondrial ribosomes and ...

One concern with in vivo CAR-Ts is the potential insertional mutagenesis of the lentiviral DNA payload, causing secondary cancers.