This study employs Heidegger's philosophy, Goal Content Theory, and Terror Management Theory to investigate the roles of intrinsic and extrinsic goals in the ...

Recent studies highlight the critical role of the cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression. This pathway is activated by cytoplasmic DNA from damaged cells, ...

Each of those three pathways has a unique enzyme that initiates the complement cascade. We found that granzyme K works differently from other proteases. It is independent because it comes from CD8 ...

This paper investigates how isoform II of transcription factor RUNX2 promotes cell survival and proliferation in oral squamous cell carcinoma cell lines. The authors used gain and loss of function ...

Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan R.O.C. Department of Physical Therapy, Hung Kuang ...

This limit could be caused by the saturation of the intrinsic signaling pathway where the intracellular signaling pathway components are fully activated and further activation of the receptors does ...

While interindividual variations in concentration and function of coagulation cascade proteins are established risk factors for venous thromboembolism (VTE), their associations with arterial ischemic ...

Our present work reveals a novel pro-apoptotic mechanism, which consists of the direct inhibition of mitochondrial protein import by bioactive lipids generated from the sphingolipid degradation ...

1 Normal vascular endothelium opposes thrombosis by resisting interactions with platelets and coagulation ... of the extrinsic and common pathway factors of the clotting cascade and is prolonged ...

Genetic studies 11 observed relatively common polymorphisms in this protein, one of which (Marburg 1) showed diminished activity in pro-urokinase activation. The present study by Willeit et al 6 ...