Huntington's disease (HD) is caused by the expansion of a CAG repeat within exon 1 of the huntingtin (HTT) gene. Although the variation in age at onset is partly explained by the lengths of the ...

HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease. George Huntington (Figure ... precisely determine the number of CAG repeats present in the HTT gene, and ...

Huntington's disease (HD ... The number of repeats inversely correlates with the age at onset, such that children with HD may have 100 CAG repeats or more. Accordingly, young-onset patients usually ...

Now, the researchers have learned more about what can control the traffic-controlling HTT.

People genetically susceptible to Huntington's disease ... or CAG, on one strand of the DNA and cytosine-thymine-guanine, or CTG, on the complementary strand—begin to repeat over and over ...

bit.bio’s new ioGlutamatergic Neurons HTT50CAG/WT provide a human, cell-based, in vitro model of Huntington’s Disease (HD) that accurately ... used to introduce an abnormal expansion of 50 CAG repeats ...

This promising strategy could slow or halt Huntington's disease progression at the root of its genetic cause. "Targeting MSH3 is exciting not only because it's directly involved in the CAG repeat ...

University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington's disease?

A decade ago, UB researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s ... Disease. When the HTT gene mutates, it ...

They found that two specific signaling proteins, GSK3β and ERK1, were expressed more in the neurons of Huntington's disease ... it repeats the genetic sequence cytosine-adenine-guanine (CAG ...