An expansion of a hexanucleotide repeat in the C9ORF72 gene can cause ALS. Here, the authors develop a high-fidelity RNA-targeting CRISPR system to suppress the repeat RNA expressed from the ...

Formerly known as Lou Gehrig’s disease, amyotrophic lateral sclerosis is now commonly referred ... like minor and limited muscle weakness, but they worsen with time. Although some treatments ...

Primary lateral sclerosis (PLS) is a motor neuron disease that occurs when the nerve cells in muscles slowly deteriorate. This leads to weakness ... is less common than amyotrophic lateral ...

It affects men more often than women, and usually as symptoms begin later in life than the actual Amyotrophic Lateral Sclerosis. People with Progressive Muscular Atrophy usually notice weakness in ...

Half of ALS patients experience constipation, which is associated with faster progression and lower survival rates, per a ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder ... may lead to misdiagnoses where the prevalence of HD is low. Predominant atrophy and weakness of the medial hand ...

Amyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease characterised by motor neuron degeneration typically presenting with muscle weakness and atrophy.1 Respiratory failure ...

We also calculated the maximum standardised uptake value (SUVmax) in all four limbs of the patients with PM/DM as well as in 22 patients with amyotrophic lateral sclerosis (ALS ... showed symmetrical ...

targeting calpain-2 for people living with amyotrophic lateral sclerosis (ALS). With the clinical hold lifted, Amylyx is now working to open U.S. sites for screening, enrollment, and dosing.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that remains incurable, despite decades of basic and clinical research. Key stakeholders—including the US National ...