Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...

The design of such enzymes that can recognize longer DNA sequences is particularly complex, however, as DNA recognition and cutting take place in one protein segment. Another result of this research ...

The duo wrote out the repeat sequences one under the other and noticed a pattern ... because it was so difficult to make zinc finger nucleases work specifically,” Boch explained. By contrast, with the ...

Here the authors reveal that zinc finger protein 207 interacts with the ... The cis-regulatory elements encoded in the sequence and structure of mRNAs determine their translational output.