The "NMDA receptor hypofunction hypothesis" proposes that reduced activity at NMDA receptors contributes to the disorder's cognitive symptoms and negative symptoms like emotional flatness and ...

Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.

Researchers at Bexson Biomedical Inc. and Saint Joseph’s University have synthesized NMDA receptor antagonists reported to be useful for the treatment of neurological and psychiatric disorders.