SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads.

RSC Medicinal Chemistry publishes significant research in medicinal chemistry and related drug discovery science. Research articles published in this journal must show a breakthrough or significant ...

R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett 17:4128-4130. [PubMed] Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL ...

Here I am integrating my knowledge in medicinal chemistry and molecular imaging into using chemical biology approaches to investigate the modulation of Hsp90 networks in cancer and neurodegenerative ...

The elucidation of the structure of several TLRs may aid medicinal chemistry in the rational design of small-molecule agonists and antagonists. Agonists for TLR4, TLR7, TLR8 and TLR9 are being ...

Research in our lab is focused on the application of medicinal chemistry in the design and synthesis of new bioactive molecules. We incorporate several computational such as molecular modeling and ...

Oct. 23, 2024 — Science laboratories across disciplines--chemistry, biochemistry and materials science--are on the verge of a sweeping transformation as robotic ... Ultra-Sensitive Electronic ...

Saluste, C.G., Ortega M.A., Pastor, J. et al. “Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors. Plos One, 2012 ...

Target discovery of bioactive natural products with native-compound-coupled CNBr-activated Sepharose 4B beads (NCCB): Applications, mechanisms and outlooks. In situ click chemistry-based discovery ...

Channel your curiosity and perseverance into a stimulating career in medicinal chemistry. Your contributions will go a long way in improving the quality of life for many. With a BS in Medicinal ...

Medicinal chemistry, also known as pharmaceutical chemistry, is a branch of chemistry focused on the development of new drugs and the improvement of existing ones. It is an interdisciplinary field ...