Image Credit: Imageforge / Shutterstock.com In the body, valproic acid undergoes a reaction to become valproate ions, which are responsible for the pharmacological effects of the drug.

FDA warns of birth defects with valproate sodium, valproic acid, and divalproex sodium December 3, 2009 ...

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism Christensen J, Grønborg TK, Sørensen MJ, et al JAMA. 2013;309:1696-1703.

That drug, valproic acid, is used to treat epilepsy, migraines and bipolar disorder. It's the active ingredient in drugs like as Depakote or Depakon, among other names.

Results Proliferation assays showed treatment with valproate or vorinostat decreased proliferation in both cell lines. Histone deacetylase inhibition also increased relative expression of ...

The results, appearing online this month in Neurology, may give hope to researchers who are midway through a larger trial to look at valproic acid in Alzheimer disease (see below). The HIV trial ...

We explored in a phase I/II clinical trial the combination of valproic acid (VPA), a clinically available histone deacetylase inhibitor, with standard chemoimmunotherapy in patients with advanced ...

Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins. Mol Med 2008; 14: 20–27. Article CAS Google Scholar ...

Valproic acid is an anticonvulsant medication that works by changing the concentration of certain neurotransmitters in the brain. It is most commonly used in the prevention of epileptic seizures ...