Of the 91 patients originally diagnosed with PMA, 20 subsequently developed upper motor neuron signs, which would qualify them as having ALS with lower motor neuron onset. Furthermore, upper motor ...

Motor neuron disease (MND), often referred to by the name of one of its varieties, ALS, is a degenerative condition ... important to recognize the early signs of MND, so that people can get ...

Despite the lower ALS risk, heart and metabolism problems are tied to faster disease progression and worse survival in the ...

Multiple models have been proposed for the mechanism by which mutant superoxide dismutase 1 induces motor neuron death and amyotrophic lateral sclerosis ... degeneration of upper and lower ...

Motor neurone disease is a group of diseases that affect the nerve cells in the brain and spinal cord that tell your muscles what to do. Also known as ALS ... is in the upper part of the spinal ...

mimicking ALS motor neuron responses. “Our approach provides a robust platform for studying ALS-specific cellular vulnerabilities and offers unprecedented opportunities for drug screening ...

ALS, also known as Lou Gehrig's disease, is the most common degenerative motor neuron disease in adults. It is characterized by a selective loss of motor neurons, resulting in progressive muscle ...

PrimeC, a fixed-dose combination of two FDA-approved drugs, ciprofloxacin and celecoxib, targets multiple ALS disease pathways such as motor neuron degeneration, inflammation, and RNA regulation.