Tic tac toe is a classic game. It can be played virtually anywhere and on anything, from a bar napkin to a computer screen to a chic wooden set. When you’re the first one up, there is a simple ...

Qian Lab/Caltech To create their game of tic-tac-toe, Qian et al. mixed up a solution of blank tiles in a test tube and let it self-assemble into a game board.

The world’s tiniest game of Tic-Tac-Toe is played using DNA and takes six days to complete, but the game was about much more than simply crowning a winner, Kristin Houser explains for Futurism.