The process of 'translation' in protein synthesis involves formation of a peptide bond between two amino acids that are attached to two distinct transfer RNAs (tRNAs). For long, scientists have ...

Several examples of peptide ligation is available, such as: the synthesis of a clickable RGD peptide (made by reacting Lys side chain with azido acetic acid) that can be clicked to another peptide ...

This is a dehydration synthesis reaction (also known as a condensation reaction), and usually occurs between amino acids. The resulting CO-NH bond is called a peptide bond, and the resulting ...

The process of “translation” in protein synthesis involves formation of a peptide bond between two amino acids that are attached to two distinct transfer RNAs (tRNAs). For long, scientists ...

In peptide manufacturing, therefore, “you need an average 99+ percent yield at each step, and there is little room for error,” said Didier Monnaie, Ph.D., project leader, Lonza, and Six Sigma ...

These scientists are stepping it up, though; a group led by Bradley L. Pentelute of MIT has developed a fully automated flow approach to solid-phase peptide synthesis that can make an amide bond ...

Current strategies for the prebiotic peptide bond synthesis rely on α-aminonitrile ligation in water and the use of wet/dry cycles for the condensation of amino acids.

CPDY has been reported to catalyze peptide bond formation from N-protected amino-acid derivatives under alkaline conditions. 29 Thus, the effect of buffer pH at alkaline conditions (pH=7–10) on ...

Ting Wang, Samuel J. Danishefsky, Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles, Proceedings of the National Academy of Sciences of the United States of ...