Recent advances in computational protein design have depended mainly on neural networks and machine learning to generate ...

Temporary protein-protein bonds are essential for processes including enzymatic reactions, antibody binding, and response to medication. Being able to accurately characterize these bonds is ...

May 15, 2006 (Vol. 26, No. 10) Finding Real Associations and Small Molecule Starting Points on the New Therapeutic Frontier Recombinant therapeutic proteins are a rapidly growing category of the ...

During DNA replication, the classic double helix can temporarily rearrange into an alternative structure known as a DNA three ...

Scientists have uncovered a molecular "on–off" switch that helps lung adenocarcinoma—the most common form of lung cancer—grow ...

A new drug targets RAS-PI3Kα pathways without harmful side effects. It was developed using high-performance computing and AI. A new cancer drug candidate, developed through a collaboration between ...

In the body, the glue molecule first binds to a type of enzyme called an E3 ubiquitin ligase, altering the shape of the ligase’s surface so it can then bind to the target protein. Once all three ...