Original Research Article Published: 22 July 2003 Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice E T Tzavara ...

Myopia, a leading cause of visual impairment globally, can progress to serious complications like retinal and choroidal degeneration. While atropine is commonly used to manage childhood myopia, its ...

Daniel M. Michaelson, Sofia Avissar, Yoel Kloog, Mordechai Sokolovsky, Mechanism of Acetylcholine Release: Possible Involvement of Presynaptic Muscarinic Receptors in Regulation of Acetylcholine ...

Muscarinic Acetylcholine Receptor M2 Antagonist Pipeline Insight – 2025 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non ...

In this study, the scientists used [11 C]MK-6884 to probe M4 receptor activity in the brain. The tracer is a cooperative positive allosteric modulator, meaning it increases binding of the M4 receptors ...

Karuna's lead program, KarXT, is a product candidate consisting of x anomeline, a novel muscarinic acetylcholine receptor agonist that has demonstrated efficacy in placebo-controlled human trials ...

Although antipsychotics that are approved for schizophrenia work primarily by antagonizing D2 dopamine receptors, 6 evidence suggests that the muscarinic cholinergic system is also involved in the ...

The fine balance between potency and selectivity that looms large in drug development has long stymied efforts to target the M1 muscarinic acetylcholine receptor (mAChR) for treatment of Alzheimer ...

ACADIA Pharmaceuticals Inc. (Nasdaq: ACAD) and Vanderbilt University today announced an exclusive worldwide license agreement to develop and commercia ...

Acetylcholine receptor antagonists are drugs that block acetylcholine from binding to its receptors, inhibiting parasympathetic nerve signals and affecting functions like muscle contraction, gland ...