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Researchers have identified how cancer cells exploit ordinary metabolic processes to manipulate immune cells, supporting ...

The work entitled " Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit" was published on Protein & Cell (published on Mar. 26 ...

When macrophages are actively fighting infections or responding to inflammation (as is the case with IBD), they activate a protein called hypoxia-inducible factor 1-alpha, or HIF-1α, to help them ...

Those animals were found to have increased macrophage density in the left ventricle and exhibited elevated levels of a factor called IL-10, which is known to contribute to fibroblast activation.

The study investigates how the myocardial infarction (MI) microenvironment affects the reprogramming of cardiac fibroblasts (CFs) into cardiomyocytes (CMs), focusing on the role of macrophages and ...

“The results suggest a potential mechanism, at the tissue level and involving macrophages, of how pulmonary fibrosis originates,” says the study’s first author Ying Xu, a PhD candidate in Zhao’s lab.

The activated fibroblasts produced profibrotic cytokines, contributing to the pathogenesis of IPF. Thus, the data emphasize a critical role for lung macrophages in the development of lung fibrosis.

HIF-1α+ macrophages can become dysregulated, however, causing their fibroblast-activating signals to get stuck in the "on" position.