Purpose: The association of methadone with Q-T interval prolongation and torsades de pointes (TdP ... action potentials that are expressed as long Q-T intervals, and methadone has been found ...

A prolonged QT interval increases the risk of polymorphic ventricular tachycardia (Torsades de Pointes) which can result in sudden cardiac death. Long QT 1: The ECG shows broad based T waves.

A prolonged QT interval has a variety of causes and can be a very serious ECG finding, as it may lead to the potentially fatal arrhythmia polymorphic ventricular tachycardia (Torsades de Pointes).

mayo.edu Congenital long QT syndrome (LQTS) affects an estimated 1 in 2500 people ... with QTc exceeding 500 ms who was just externally defibrillated from torsades de pointes while swimming poses ...

Am J Health Syst Pharm. 2009;66(9):825-833. In the same article, the authors sought to evaluate the relative contribution of chlorobutanol (a preservative found in the only parenteral methadone ...