Nature

Effect of Exogenous Surfactant on the Development of Surfactant Synthesis in Premature Rabbit Lung

The biophysical activity associated with lung surfactant is achieved through the complex interaction of a mixture of phospholipids and SP-A, SP-B, and SP-C (1–4). The lipid and protein surfactant ...
Medscape

Mechanisms of Acute Respiratory Distress Syndrome in Children and Adults

Pediatr Crit Care Med. 2013;14(6):631-643. Future studies of the effect of exogenous surfactant in children and adults with ARDS should use the same surfactant and include a study design that can ...
JSTOR Daily

Exogenous Bovine Surfactant Suppresses Tumor Necrosis Factor-α Release by Murine Macrophages Stimulated by Genital Mycoplasmas

Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that appears to play a significant role in the development of neonatal chronic lung disease (CLD). Inflammation and CLD are also ...
Medscape

Multicenter, Randomized, Controlled Study of Porcine Surfactant in Severe Respiratory Syncytial Virus-Induced Respiratory Failure

Objective: Recently, natural exogenous surfactant replacement has been used in experimental models and clinical trials for the treatment of severe respiratory syncytial virus (RSV) disease. The ...
FierceBiotech

Discovery Labs Announces FDA Approval of SURFAXIN to treat Respiratory Distress Syndrome

SURFAXIN is the First FDA-Approved Synthetic, Peptide-Containing Surfactant WARRINGTON, Pa., March 6, 2012 /PRNewswire/ -- Discovery Laboratories, Inc. (NASDAQ: DSCO), a specialty biotechnology ...
Medicine Buffalo

Infasurf: Lifesaving Treatment for Premature Babies

President John F. Kennedy would have had another heir had his second son not died from respiratory distress syndrome (RDS). The disease—caused by developmental insufficiency of surfactant production ...