The Kaposi’s sarcoma herpesvirus encodes a G-protein-coupled chemokine receptor termed KSHV-GPCR. Expression of this constitutively active GPCR leads to cell transformation and vascular ...

Patients who were positive for CXCR2 expression had higher survival rates, according to both Kaplan-Meier curves (P = .042) and multivariate logistic regression analysis (P = 0.031).

Serum levels of CYFRA 21-1, CXCR1, %, lymphocytes, and CXCR2, %, monocytes in peripheral blood were measured before treatment and at three weeks, three months, and six months after treatment using ...

Figure 2: CXCR2-mediated NET formation is NADPH oxidase independent. Figure 3: NET formation in cystic fibrosis lung disease. To demonstrate that NETosis in cystic fibrosis airway fluids is ...

RIST4721 is an oral CXCR2 antagonist being developed by Aristea. Under the terms of the agreement, Arena will pay upfront $60 million to Aristea and make a $10 million equity investment in Aristea ...

Pairing Merck’s investigational CXCR2 inhibitor navarixin (MK-7123) with Pfizer and Astellas’ anti-androgen drug Xtandi (enzalutamide) killed CRPC in a mouse model, the team showed.

CXCR2 Structure: Using cryogenic-electron microscopy (cryo-EM), the research team has mapped the structure of CXCR2, revealing how it interacts with various chemokines. These findings could serve ...

Background: A component of the epithelial to mesenchymal transition (EMT) is degradation of extracellular matrix and acquisition of migration, both of which support invasiveness. The expression of ...

Results: Digital IHC quantification of archival human CCA specimens demonstrated elevated levels of CD15 + CXCR2 + granulocytic myeloid derived suppressor cells (G-MDSC) compared to adjacent normal ...

G protein-coupled receptors (GPCRs) are involved in many diseases, yet raising therapeutic antibodies against them is notoriously difficult because the transmembrane receptors contain only short ...