Thin, flexible protein strands called actin filaments act like bones for our cells and are critical for its movement. Supercomputer simulations have helped solve a decades-old mystery of how actin ...

The data also detailed the structural changes induced by two actin filament-capping proteins, CapZ at the barbed end and tropomodulin at the pointed end.

According to the dogma, these monomers are typically added to just one end of the actin filament, called the barbed end, and removed from the opposite end, called the pointed end. Cyclase-associated ...

Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nature Structural & Molecular Biology, 2023; DOI: 10.1038/s41594-023-01101-9 ...

The dynamics of actin filaments are governed largely by the "treadmilling" process, through which individual actin proteins are shed from one filament end, known as the pointed end, and added at ...

Actin is the most abundant protein inside the cells of higher organisms, such as animals. It serves as the building-block for long, thin structures called filaments, which provide key structural ...

Further studies are required to elucidate how the balance between N-WASP stability, barbed end capping and ARP2/3-complex-dependent actin nucleation is achieved and how this might affect filament ...

Our recent work in this area addresses functional cross-talk between the actin and microtubule cytoskeletons regulated by a triad of mammalian proteins that physically associate: (a) the tumor ...