Sicily is an island in the central Mediterranean Sea, south of the Italian Peninsula in continental Europe and is one of the 20 regions of Italy. With 4.8 million inhabitants, including 1.3 million in and around the capital city of Palermo, it is the most populous island in the Mediterranean Sea. It is named after the Sicels, who inhabited the eastern part of the island d…Sicily is an island in the central Mediterranean Sea, south of the Italian Peninsula in continental Europe and is one of the 20 regions of Italy. With 4.8 million inhabitants, including 1.3 million in and around the capital city of Palermo, it is the most populous island in the Mediterranean Sea. It is named after the Sicels, who inhabited the eastern part of the island during the Iron Age. Sicily has a rich and unique culture in arts, music, literature, cuisine, and architecture. Its most prominent landmark is Mount Etna, the tallest active volcano in Europe, and one of the most active in the world, currently 3,357 m high. The island has a typical Mediterranean climate. It is separated from Calabria by the Strait of Messina. It is one of the five Italian autonomous regions and is generally considered part of Southern Italy.